Over 3 million clinicians around the world depend on UpToDate to guide patient care, and now the gold standard in clinical decision support is integrating generative AI. But in a world where AI models often hallucinate, how do you build something that doctors can actually trust?

Most people spend over 30 hours a year dealing with customer service—on hold, repeating account numbers, and navigating endless phone trees. But what if AI could fix that without losing the human touch?

Hospitals are under immense pressure: burned-out clinicians, outdated systems, and rising costs have made delivering care harder than ever. 

Fresh off a $240 million fundraise from Oak HC/FT and A16Z, Ambience Healthcare is on a mission to kill medical billing — and build “Iron Man suits for doctors.”

More than a thousand AI medical devices have FDA clearance, yet fewer than two percent of radiologists actually use them.

Most AI in healthcare promises superintelligence—but what if that’s the wrong goal entirely?

US healthcare has more unproductive labor and more unstructured data than any other industry, making it both especially vulnerable to disruption from generative AI and especially unprepared for it.

Startup accelerator and venture capital firm Y Combinator has a long history of backing early-stage healthcare startups, with a particular focus on technical founders tackling difficult problems. In this episode, YC partners Jared Friedman and Ankit Gupta share their insights on healthcare investing, the potential of AI in our industry, and why they believe young, tactical founders can play a role in reshaping healthcare.

Full-body MRIs are a controversial and expensive screening tool that some believe could revolutionize early cancer detection, while others worry they create unnecessary anxiety and waste medical resources.

In this episode, we dive deep into this debate with Emi Gal, founder & CEO of Ezra, who is using AI to make full-body MRI screening faster, more accessible, and more accurate.

Join us for many mic-drop moments with recording artist-turned-healthcare-investor D.A. Wallach.

Technology is transforming genetic testing and bringing hope to families facing rare diseases. GeneDx (Nasdaq: WGS) CEO Katherine Stueland sits down with Steve Kraus to share how AI is being used to crack life's most complex code and speed up diagnosis from years to days.

Clinical notes are one of the more tedious parts of doctors’ day-to-day lives—so much so that they’re often called “pajama time,” since physicians spend 2-3 hours writing them at night. In this episode, Steve Kraus sits down with Dr. Shiv Rao, co-founder and CEO of Abridge, an AI-first healthcare company that’s been in the spotlight for solving this problem. Abridge uses advanced machine learning to structure and summarize medical conversations, creating clinical documentation and structured data while reducing clinician burnout.

Shiv traces his journey from a skateboarding rebel to a cardiologist, professor, healthcare investor, and now founder of a pioneering digital health startup. He shares how his passion for scalable impact and exposure to cutting-edge research at Carnegie Mellon led him to start Abridge in 2018.

In this episode, former Facebook product manager and internationally recognized whistleblower, Frances Haugen offers invaluable insights into how tech giants prioritizes profits over public safety, and the profound implications this has on mental health of young people.

We explore her brave journey, which took her from the inner workings of Meta to testifying before the world's parliaments, sparking a global conversation about the role and regulation of social media. Listen in as we shed light on the pressing issues of our digital era, and the steps we can take to safeguard vulnerable populations from social media's impacts.

In this episode, we sit down with Dr. Eric Topol, the godfather of digital health, to explore the progress and barriers to innovation in healthcare, the potential of AI in transforming the industry, and the challenges faced by startups and big tech companies. Dr. Topol shares his insights on open-source healthcare, evaluating new innovations, and the importance of algorithmic fairness. Tune in to gain deep insights into the future of medicine and the power of technology in reshaping healthcare.

The healthcare industry has made significant strides in the past 20 years… or has it? In this episode, we sit down with Adrian Aoun, CEO of Forward, an AI-based healthcare system, to discuss how artificial intelligence (AI) can help us achieve exponential improvements to human health.