On the heels of raising $210 million at a $3.5 billion valuation, OpenEvidence is the fastest-growing physician app in history, now reaching over 40% of U.S. physicians and powers 17 million monthly clinical queries.

Most people spend over 30 hours a year dealing with customer service—on hold, repeating account numbers, and navigating endless phone trees. But what if AI could fix that without losing the human touch?

This milestone 200th!!! episode of The Heart of Healthcare Podcast features none other than Dr. Tom X. Lee, the serial physician-founder behind Epocrates (acquired for $293M), One Medical (acquired by Amazon for $3.9B), and now Galileo, a tech-enabled medical group aiming to rewire care delivery from the ground up.

Hospitals are under immense pressure: burned-out clinicians, outdated systems, and rising costs have made delivering care harder than ever. 

Three simple questions plague every American seeking healthcare: Where should I go? When can I be seen? And how much will it cost me? Despite seeming basic, these questions have remained largely unanswerable—until now.

Fresh off a $240 million fundraise from Oak HC/FT and A16Z, Ambience Healthcare is on a mission to kill medical billing — and build “Iron Man suits for doctors.”

When Andrew Lacy launched Prenuvo, most of the medical establishment dismissed it as fringe. Now, some of those same skeptics are collaborating with him on research.

In their first podcast since going public, Omada Health CEO Sean Duffy joins us to reflect on the journey to bend the curve of chronic disease.

What does one do after selling their company to Amazon for $1 billion? Start a new one, of course.

Most AI in healthcare promises superintelligence—but what if that’s the wrong goal entirely?

Each year, 2 million Americans are diagnosed with cancer and face a fragmented, overwhelming healthcare system with minimal guidance between doctor visits, even as they make life-altering decisions.

In this episode, we talk with Mario Schlosser, co-founder and CTO of Oscar Health, about building a tech-first health insurance company in an industry notorious for poor customer experiences.

From law school to leading one of healthcare's most successful value-based care companies, Oak Street Health co-founder Mike Pykos shares the story of building, scaling, and ultimately selling his company to CVS for $11 billion.

He reveals the challenges of scaling a new care model, the importance of focusing on outcomes over financials, and what it takes to transform American healthcare.

After building and selling Meebo, Seth Sternberg wanted his next venture to transform lives at scale. A decade later, Honor has become the world's largest in-home senior care network, delivering care to 35,000 US homes daily. In this candid conversation, Sternberg reveals how AI saved the company from near collapse in 2015 and why treating caregivers like true professionals creates better outcomes for everyone.

"There's been a degree of toxic positivity in US healthcare," says Dr. Sachin Jain, CEO of SCAN Health Plan. In this candid conversation about healthcare's need for radical change, Dr. Jain challenges industry orthodoxy and calls for a leadership revolution. From Medicare Advantage turbulence to the failures of healthcare consolidation, he offers an insider's view of what needs to change.

In this episode, Christine Lemke, co-founder and CEO of Evidation Health, shares how her personal struggles with chronic pain fueled her mission to transform how we measure and improve health outcomes. She shares the company's evolution and innovative approach to generating real-world evidence (RWE) using a global research platform serving millions of people.

In this episode, Glen Tullman reflects on the biggest changes he's seen in healthcare during his 40-year career in the industry. Glen is the founder and CEO of Transcarent, former founder and CEO of Livongo, and managing partner at 7wireVentures.

Clinical notes are one of the more tedious parts of doctors’ day-to-day lives—so much so that they’re often called “pajama time,” since physicians spend 2-3 hours writing them at night. In this episode, Steve Kraus sits down with Dr. Shiv Rao, co-founder and CEO of Abridge, an AI-first healthcare company that’s been in the spotlight for solving this problem. Abridge uses advanced machine learning to structure and summarize medical conversations, creating clinical documentation and structured data while reducing clinician burnout.

Shiv traces his journey from a skateboarding rebel to a cardiologist, professor, healthcare investor, and now founder of a pioneering digital health startup. He shares how his passion for scalable impact and exposure to cutting-edge research at Carnegie Mellon led him to start Abridge in 2018.