Hospitals are under immense pressure: burned-out clinicians, outdated systems, and rising costs have made delivering care harder than ever. 

Three simple questions plague every American seeking healthcare: Where should I go? When can I be seen? And how much will it cost me? Despite seeming basic, these questions have remained largely unanswerable—until now.

Fresh off a $240 million fundraise from Oak HC/FT and A16Z, Ambience Healthcare is on a mission to kill medical billing — and build “Iron Man suits for doctors.”

When Andrew Lacy launched Prenuvo, most of the medical establishment dismissed it as fringe. Now, some of those same skeptics are collaborating with him on research.

In their first podcast since going public, Omada Health CEO Sean Duffy joins us to reflect on the journey to bend the curve of chronic disease.

What does one do after selling their company to Amazon for $1 billion? Start a new one, of course.

Most AI in healthcare promises superintelligence—but what if that’s the wrong goal entirely?

Each year, 2 million Americans are diagnosed with cancer and face a fragmented, overwhelming healthcare system with minimal guidance between doctor visits, even as they make life-altering decisions.

In this episode, we talk with Mario Schlosser, co-founder and CTO of Oscar Health, about building a tech-first health insurance company in an industry notorious for poor customer experiences.

From law school to leading one of healthcare's most successful value-based care companies, Oak Street Health co-founder Mike Pykos shares the story of building, scaling, and ultimately selling his company to CVS for $11 billion.

He reveals the challenges of scaling a new care model, the importance of focusing on outcomes over financials, and what it takes to transform American healthcare.

After building and selling Meebo, Seth Sternberg wanted his next venture to transform lives at scale. A decade later, Honor has become the world's largest in-home senior care network, delivering care to 35,000 US homes daily. In this candid conversation, Sternberg reveals how AI saved the company from near collapse in 2015 and why treating caregivers like true professionals creates better outcomes for everyone.

"There's been a degree of toxic positivity in US healthcare," says Dr. Sachin Jain, CEO of SCAN Health Plan. In this candid conversation about healthcare's need for radical change, Dr. Jain challenges industry orthodoxy and calls for a leadership revolution. From Medicare Advantage turbulence to the failures of healthcare consolidation, he offers an insider's view of what needs to change.

In this episode, Christine Lemke, co-founder and CEO of Evidation Health, shares how her personal struggles with chronic pain fueled her mission to transform how we measure and improve health outcomes. She shares the company's evolution and innovative approach to generating real-world evidence (RWE) using a global research platform serving millions of people.

In this episode, Glen Tullman reflects on the biggest changes he's seen in healthcare during his 40-year career in the industry. Glen is the founder and CEO of Transcarent, former founder and CEO of Livongo, and managing partner at 7wireVentures.

Clinical notes are one of the more tedious parts of doctors’ day-to-day lives—so much so that they’re often called “pajama time,” since physicians spend 2-3 hours writing them at night. In this episode, Steve Kraus sits down with Dr. Shiv Rao, co-founder and CEO of Abridge, an AI-first healthcare company that’s been in the spotlight for solving this problem. Abridge uses advanced machine learning to structure and summarize medical conversations, creating clinical documentation and structured data while reducing clinician burnout.

Shiv traces his journey from a skateboarding rebel to a cardiologist, professor, healthcare investor, and now founder of a pioneering digital health startup. He shares how his passion for scalable impact and exposure to cutting-edge research at Carnegie Mellon led him to start Abridge in 2018.

80% of Americans suffering from eating disorders don’t get the treatment they need. That’s where Equip comes in. In this episode, Steve Kraus sits down with Kristina Saffran, the co-founder and CEO of Equip, a virtual provider transforming eating disorder treatment by making evidence-based care more accessible to patients and families. Kristina shares her personal journey recovering from anorexia and how her experience with the challenges in traditional treatment led her to found a non-profit and ultimately start Equip.

As a medical school-bound undergrad, Sean Duffy, co-founder and CEO of Omada Health, didn’t initially consider entrepreneurship as a career path. Today, Sean leads a virtual-first care provider for chronic conditions like diabetes, hypertension, and musculoskeletal disorders. Sean traces his journey from a "techie" upbringing to stints at Google and medical school, and how his early fascination with the potential of digital health ultimately led him to build Omada.